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2 It is also accomplished by an interaction of blood cells, proteins, proteases, growth factors, and extracellular matrix (ECM) components. 1 It is a complex process accomplished by coordinated interactions between cells in the dermis and epidermis. Healing of wound is a sophisticated, strictly controlled process that plays a great role in maintaining the protective function of skin. Keywords: Aloe trigonantha, wound healing, anti-inflammatory, granuloma model, ear edema model

Aloe trigonantha leaf gel powder also produced dose-dependent significant reductions ( p< 0.05) of inflammation compared to control in both models.Д¬onclusion: Data obtained from this study collectively indicated that Aloe trigonantha is a potential wound-healing and anti-inflammatory agent in rat models of wound and inflammation which provides evidence for the traditional claim.

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Results: Treatment of wounds with ointment containing 5% and 10% (w/w) of the gel exhibited a significantly increased wound contraction rate, shorter epithelialization time, and higher skin breaking strength ( p< 0.05) compared to controls. An anti-inflammatory effect was measured by reduction of ear edema weight and reduction of wet exudate and dry granuloma weight in both of xylene-induced ear edema and cotton pellet-induced granuloma models, respectively. The leaf gel powder of Aloe trigonantha was given orally at a dose of 100, 200, and 400 mg/kg in both models of anti-inflammatory studies. A Xylene-induced ear edema model and cotton pellet-induced granuloma model were used for anti-inflammatory study. For the excision wound model, wound contraction and period of epithelialization were evaluated, while wound tensile strength was evaluated using an incision wound model. Excision and incision models were used for wound healing activity in rats. It was evaluated for wound healing activity topically by incorporating it in a simple ointment base at a concentration of 5% (w/w) and 10% (w/w). Methods: The leaf gel powder of the Aloe trigonantha was prepared after the gel gets lyophilized. Therefore, the present study aimed at evaluating the in vivo wound healing and anti-inflammatory effects of the leaf gel of the plant in rats.

However, there were no in vivo studies which prove its claimed use for wound healing and anti-inflammatory activity.

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Haile Tazeze, 1 Solomon Mequanente, 2 Dereje Nigussie, 3 Belete Legesse, 4 Eyasu Makonnen, 2, 4 Teklie Mengie 5ДЎDepartment of Pharmacy, Kidus Petros TB Specialized Hospital, Addis Ababa, Ethiopia 2Department of Pharmacology & Clinical Pharmacy, School of Pharmacy, College of Health Science, Addis Ababa University, Addis Ababa, Ethiopia 3Ethiopian Public Health Institute, Addis Ababa, Ethiopia 4Center for Innovative Drug Development & Therapeutics Trial in Africa (CDT-Africa), College of Health Science, Addis Ababa University, Addis Ababa, Ethiopia 5Department of Pharmacy, College of Health Science, Debre Tabor University, Debre Tabor, EthiopiaД¬orrespondence: Teklie Mengie P.O.Box:272, Debre Tabor, 6300, EthiopiaД«ackground: Traditionally Aloe trigonantha leaf is used for the treatment of different diseases.

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